LL-37

Potential Benefits of LL-37 Peptide

• LL-37 peptide exhibits potent antimicrobial and anti-biofilm properties, making it a potential candidate for treating bacterial infections and biofilm-related diseases [1] and [2].
• The peptide has been explored as a potential treatment for polymicrobial infected wounds due to its antimicrobial action [3].
• LL-37 peptide is naturally secreted by human mesenchymal stem cells, contributing to their antimicrobial effect. This finding suggests the peptide’s role in innate immunity and its potential use in stem cell therapies [4] and [5].
• Research has shown that LL-37 peptide can be successfully loaded onto nanoparticles for targeted drug delivery, indicating its potential in nanomedicine and treatment of drug-resistant bacterial infections [6].
• According to research, the antibacterial activity of LL-37 peptide can be inhibited by salivary mucins, highlighting the importance of understanding the peptide’s interactions with other biological molecules for therapeutic applications [7].
• In the context of cystic fibrosis, LL-37’s antimicrobial activity can be inhibited when complexed with glycosaminoglycans in the lungs. However, studies indicate this inhibition can be reversed by hypertonic saline, suggesting a potential therapeutic strategy [8].
• Research suggests LL-37 peptide has immunomodulatory and tissue repair properties, further expanding its therapeutic potential [9].
• There is ongoing research into the role of LL-37 peptide in COVID-19 inflammatory responses and microthrombosis, indicating its relevance in current global health issues [10].

References

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8227053/

[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5374219/

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3699762/

[4] https://www.sciencedirect.com/science/ article/pii/S2405844019363121

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3293245/

[6] https://www.sciencedirect.com/science/ article/abs/pii/S1385894722005903

[7] https://pubmed.ncbi.nlm.nih.gov/18456648/

[8] https://pubmed.ncbi.nlm.nih.gov/19542465/

[9] https://pubmed.ncbi.nlm.nih.gov/25101632/

[10] https://pubmed.ncbi.nlm.nih.gov/35634307/

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