Humanin

Potential Benefits of Humanin Peptide

• Mitochondrial Protection: According to studies, the Humanin peptide exhibits potent neuroprotective properties by acting on mitochondrial pathways. It inhibits Bax-dependent apoptosis, thereby safeguarding neuronal cells from oxidative stress and mitochondrial dysfunction [1].
• Anti-Apoptotic Effect: Studies have shown that Humanin exerts an anti-apoptotic effect through the suppression of pro-apoptotic proteins like BAX and BID. It promotes cell survival and reduces cell death [2].
• Counteracts Alzheimer’s Disease Progression: Humanin has been found to counteract Alzheimer’s disease pathology. Research suggests it interferes with amyloid-beta toxicity, one of the main culprits in the development of Alzheimer’s disease [3].
• Promotes Metabolic Homeostasis: Research suggests that Humanin can regulate glucose metabolism and improve insulin sensitivity, thus contributing to metabolic homeostasis [4].
• Anti-Aging Properties: Humanin levels decrease with age, and research suggests that supplementation with this peptide can combat age-related diseases and extend lifespan [5].
• Cardiovascular Health: Preliminary studies indicate that Humanin may protect against cardiovascular diseases by reducing myocardial ischemia/reperfusion injury and attenuating atherosclerosis [6].
• Role in Immunity: Studies indicate Humanin also plays a critical role in modulating the immune response, potentially offering protective effects against inflammatory and autoimmune disorders [7].

References

[1] https://pubmed.ncbi.nlm.nih.gov/14561895/

[2] https://pubmed.ncbi.nlm.nih.gov/12732850/

[3] https://pubmed.ncbi.nlm.nih.gov/11371646/

[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2709436/

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4925829/

[6] https://pubmed.ncbi.nlm.nih.gov/23277413/

[7] https://pubmed.ncbi.nlm.nih.gov/19477263/