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Highest Quality | For Research Use Only

Humanin

Buy Humanin Peptide Czech Republic

Humanin is a small, mitochondria-derived peptide (MDP) consisting of 24 amino acids. It was first identified as a secreted factor from a cDNA library derived from the brain of a patient with Alzheimer’s disease (AD) and has since garnered considerable attention for its potential therapeutic properties.

Humanin exerts its effects through interactions with several receptors, most notably the formyl peptide receptor-like 1 (FPRL1) and BAX, a pro-apoptotic protein. Through these interactions, Czech Republic research has suggested Humanin can inhibit apoptosis, or programmed cell death, which is implicated in numerous diseases. Importantly, the anti-apoptotic activity of Humanin is highly specific to pathological or ‘bad’ apoptosis, making it an intriguing target for therapeutic intervention.

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Potential Benefits of Humanin Peptide

  • Mitochondrial Protection: According to studies, the Humanin peptide exhibits potent neuroprotective properties by acting on mitochondrial pathways. It inhibits Bax-dependent apoptosis, thereby safeguarding neuronal cells from oxidative stress and mitochondrial dysfunction [1].
  • Anti-Apoptotic Effect: Studies have shown that Humanin exerts an anti-apoptotic effect through the suppression of pro-apoptotic proteins like BAX and BID. It promotes cell survival and reduces cell death [2].
  • Counteracts Alzheimer’s Disease Progression: Humanin has been found to counteract Alzheimer’s disease pathology. Research suggests it interferes with amyloid-beta toxicity, one of the main culprits in the development of Alzheimer’s disease [3].
  • Promotes Metabolic Homeostasis: Research suggests that Humanin can regulate glucose metabolism and improve insulin sensitivity, thus contributing to metabolic homeostasis [4].
  • Anti-Aging Properties: Humanin levels decrease with age, and research suggests that supplementation with this peptide can combat age-related diseases and extend lifespan [5].
  • Cardiovascular Health: Preliminary studies indicate that Humanin may protect against cardiovascular diseases by reducing myocardial ischemia/reperfusion injury and attenuating atherosclerosis [6].
  • Role in Immunity: Studies indicate Humanin also plays a critical role in modulating the immune response, potentially offering protective effects against inflammatory and autoimmune disorders [7].

References

[1] https://pubmed.ncbi.nlm.nih.gov/14561895/

[2] https://pubmed.ncbi.nlm.nih.gov/12732850/

[3] https://pubmed.ncbi.nlm.nih.gov/11371646/

[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2709436/

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4925829/

[6] https://pubmed.ncbi.nlm.nih.gov/23277413/

[7] https://pubmed.ncbi.nlm.nih.gov/19477263/

 

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://czech-republic.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.