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Highest Quality | For Research Use Only

IGF-1 DES

Buy IGF-1 DES Peptide Czech Republic

IGF-1 DES, or Insulin-Like Growth Factor 1 DES (1-3), is a truncated form of Insulin-Like Growth Factor 1 (IGF-1). This peptide boasts a shorter amino acid sequence, with the first three N-terminal amino acids cleaved, resulting in an overall increase in its biological activity.

The primary function of IGF-1 DES lies in its ability to stimulate growth and development of cells, primarily muscle and bone cells. This is achieved through its role in protein synthesis, where it acts as a mediator in the growth hormone (GH) signaling pathway. Upon GH binding to its receptor, IGF-1 is released, promoting cellular growth and proliferation.

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Potential Benefits of IGF-1 DES Peptide

  • Enhanced Cell Therapy for Acute Kidney Injury (AKI): A study synthesized a bioactive hydrogel by immobilizing the C domain peptide of IGF-1 (IGF-1C) on chitosan, hypothesizing that this hydrogel could provide a favorable niche for cell therapy in treating AKI [1].
  • Cognitive Benefits: Research has explored the potential cognitive benefits of growth hormone/IGF-1 treatment, particularly in aged animals. The application of des-IGF-1 has been shown to alter the release probability for glutamate, which could have implications for cognitive function [2] and [3].
  • Muscle Hypertrophy and Regeneration: Research has shown localized IGF-1 transgene expression has been found to sustain hypertrophy and regeneration in senescent skeletal muscle [4]. This could potentially be beneficial for countering sarcopenia, an age-related condition characterized by loss of muscle mass and function [5].
  • Cardiac Health: According to research, cardiac-specific IGF-1 receptor transgenic expression has been shown to protect against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy [6].
  • Potential Role in Alzheimer’s Disease Treatment: Research suggests that IGF-1 treatment could potentially be beneficial in Alzheimer’s disease (AD), although definitive assessments of the benefits and risks are still needed [7].
  • Metabolic Regulation: Research studies indicate IGF-1, stimulated by growth hormone (GH), plays a role in regulating fat, protein, and glucose metabolism [8].

References

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4978042/

[2] https://pubmed.ncbi.nlm.nih.gov/15985695/

[3] https://www.sciencedirect.com/science/ article/abs/pii/S156816370500005X

[4] https://pubmed.ncbi.nlm.nih.gov/11175789/

[5] https://pubmed.ncbi.nlm.nih.gov/30953403/

[6] https://pubmed.ncbi.nlm.nih.gov/20215428/

[7] https://pubmed.ncbi.nlm.nih.gov/22503992/

[8] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6708115/

 

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://czech-republic.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.