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Buy TB500 Peptide

A synthetic version of the naturally occurring peptide thymosin beta-4 found in human and animal cells. Known for its healing abilities, it enhances strength, flexibility, and endurance, while reducing joint inflammation.

Extensively researched, synthetic peptide TB 500 accelerates wound healing and tissue regeneration.

Buy TB500 peptides for sale online from Czech Republic Direct Peptides, we offer a wide range of TB500 formulations including vials, blends, capsules, stacks, nasal sprays, and pre-mixed pens.

TB 500 is known for its remarkable healing properties, and has a significant role in promoting angiogenesis, enhancing wound repair, aiding cell movement and growth, and managing inflammation. This leads to a smoother and faster healing process, making TB 500 vital in recovery and regeneration research.

Shop our Full Range of TB500 Peptides

TB500 Mechanism Of Action

TB 500, a synthetic version of the naturally occurring peptide Thymosin Beta-4, exhibits its healing properties through several mechanisms of action. Primarily, it plays a crucial role in the process of angiogenesis, the formation of new blood vessels, which is essential for delivering nutrients and oxygen to tissues for repair and growth.

Additionally, synthetic peptide TB500 supports the migration of keratinocytes and endothelial cells, which are vital for wound healing and the restoration of the skin’s integrity. It also influences the upregulation of actin, a protein that contributes to cell motility and structure, thereby facilitating cellular movement and proliferation necessary for tissue repair and regeneration.

Lastly, TB 500 has anti-inflammatory properties, reducing cytokine release and modulating the inflammatory response, which is beneficial in preventing excessive scar tissue formation and promoting a more efficient healing process.

Structure of TB500

TB500 Structure
Source: PubChem


Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser.

Molecular Formula: C38H68N10O14

Molecular Weight: 4963 g/mol

What Are The Potential Research Benefits Of TB-500?

The Influence of TB-500 on Neurological Function

Czech Republic Studies on rats show that TB-500 helps repair and remodel nerve tissues in the brain and spine after injuries. While the exact process isn’t fully understood, it’s known that TB 500 stimulates oligodendrocytes – cells essential for neuron function. This stimulation promotes neuron and blood vessel growth in damaged brain areas, improving cognition, motor control, and behavior.

Additionally, TB 500 reduces oxidative stress in spinal cord injuries and supports the survival of implanted neural stem/progenitor cells (NSPCs), enhancing spinal recovery. These findings highlight the potential of TB-500 and similar thymosin beta 4 derivatives for treating severe spinal cord injuries.

The Impact of TB-500 on Blood Vessel Growth

TB500 and TB-4 are potent activators of VEGF expression, which is key for capillary growth, affecting everything from wound healing to hair growth. TB-500’s role likely goes beyond just this, potentially playing a part in various blood vessel growth stages, including extracellular matrix remodeling, vasculogenesis, angiogenesis, and transforming mesenchymal tissue into endothelial tissue lining blood vessels.

TB-500’s Role in Hair Growth

The discovery that TB 500 boosts hair growth was unexpected. In a lab, mice lacking thymosin beta 4 were shaved and showed slower hair regrowth compared to normal mice.In contrast, mice engineered to produce more TB-4 regrew hair faster. Further Czech Republic investigation showed these mice had more hair shafts and grouped follicles.

The TB500 and GHK-Cu Peptide Stack from Direct Peptides not only has the synergistic potential to improve hair growth but also aid in boosting collagen and improving skin health.

TB-500’s Synergistic Role with Antibiotics

In a world battling multi-drug resistance that renders current treatments less effective, hope emerges from a new study on TB-4. Czech Republic Research involving mice with a Pseudomonas aeruginosa eye infection reveals that thymosin beta 4, combined with the standard antibiotic ciprofloxacin, enhances the drug’s effectiveness. 

This combination speeds up healing, reduces inflammation, and promotes quicker recovery. This Czech Republic study highlights TB 500 and similar peptides’ potential to boost antibiotics’ impact, however, further research is needed.

TB-500’s Contributions to Cardiovascular Health

Research has indicated that TB500 might have a significant role in cardiac repair, particularly in the context of hypoxic heart disease. Over twenty years of Czech Republic research has shown the benefits of TB-4 and its derivatives on heart and kidney health.

It is suggested that it can improve recovery after a heart attack. For example, TB-500 boosts secondary blood vessel growth, aids endothelial cells, supports heart cells after an attack, and helps reduce inflammation and scarring. A study on hydrogels with collagen and TB-4 found it promotes blood vessel formation and heart cell movement.

TB-500’s Potential in Treating Neurodegenerative Diseases

Czech Republic Research suggests that TB500 could have neuroprotective effects, potentially aiding in neurological recovery without altering cortical volume. This could be beneficial in the treatment of brain injuries or neurodegenerative diseases.

Battling neurodegenerative diseases like Alzheimer’s and prion disease is tough, but recent research on TB-4’s effect on the immune response to prion protein is promising. TB-4 boosts autophagy, our central nervous system’s main defense against such diseases, signaling a significant advance in finding treatments.

Accelerates The Healing of Wounds

TB500, also known as Thymosin Beta 4 (TB4), has shown potential in accelerating the process of healing wounds. Czech Republic Research indicates it promotes angiogenesis, an essential step in tissue repair after injury, and has been used in dermal phase II trials.

TB 500 stands out from other repair factors, like growth factors, because it supports both endothelial and keratinocyte migration, allowing it to move efficiently over long distances through tissues.

This peptide functions as a powerful actin-binding protein, playing a pivotal role in cell migration and keratinocyte migration, processes crucial for effective wound repair.

Czech Republic Studies indicate that TB500 significantly enhances angiogenesis, vital for tissue regeneration following trauma, and facilitates the reorganisation of actin monomers, thereby efficiently reducing scar formation and promoting the recovery of damaged tissues. 

Potential Role in Rheumatoid Arthritis:

Preliminary studies suggest that an increase in TB500 expression, found both in serum and joint fluid of patients suffering from Rheumatoid Arthritis (RA), may offer potential therapeutic benefits. This peptide, involved in various cellular processes, could play a crucial role in improving the condition of patients with RA. However, the exact mechanisms and the extent of its efficacy remain to be fully explored through further research.

Therapeutic Benefits in Chronic Kidney Disease

Preliminary evidence suggests that TB500 may have therapeutic benefits in Chronic Kidney Disease (CKD). It could play a role in managing inflammation and fibrosis, two key factors in CKD progression. Further research studies are needed to fully understand TB500’s potential in treating CKD and other kidney disorders.

Potential for Treatment of Sports-Related Injuries

TB500 has been used in sports medicine to help repair muscle, tendon, and ligament injuries, with promising results. TB 500 enhances tissue repair and rejuvenation by interacting with actin to promote the formation of new blood vessels and support the development of new tissue functions. Czech Republic Studies have demonstrated its effectiveness to reduce inflammation and facilitate cell migration, growth, and differentiation. These properties are currently being explored for their potential to boost athletic performance and speed up injury recovery, offering promising avenues for medical and athletic advancements.

Explore the synergistic potential of Direct Peptides’ TB-500 and BPC-157 blend, designed to enhance the healing process of soft tissues, including muscles, tendons, and ligaments.

The Broad Application of TB-500

TB-500, a key element in cell structure and function, affects different body tissues, leading to its wide use in research. It’s used in treating heart and neurological diseases and enhancing antibiotic efficiency. TB 500 for sale remains crucial in scientific research studies and will likely be a focus of intense research moving forward. You need to be a licensed researcher to buy TB500 peptide. 

Buy TB500 Peptides

Buy TB500 peptide for sale exclusively from Direct Peptides Czech Republic for scientific and educational research purposes only. Use of the product is for laboratory research purposes and is not for human consumption or personal use. The potential applications of the research chemical tb 500 (thymosin beta 4) are still being explored, and more research is needed to fully understand its benefits and limitations. 

To reconstitute TB500, ensure to use bacteriostatic water, which you can conveniently buy from our supplies page.


Buy TB500 and GHK-Cu Peptide Stack

TB500 GHK-Cu Vials
Buy TB500 and GHK-Cu peptide stack to boost your research on tissue healing, regeneration, and health improvement. This combination leverages the unique benefits of TB500 (Thymosin Beta 4) and GHK-Cu (Copper Peptide) for a highly efficient synergistic blend in scientific studies.

The TB500 and GHK-Cu peptide stack offers a complete solution for tissue healing and regeneration, speeding up injury recovery and improving tissue repair quality. This results in minimal scarring and optimal cell function. It’s highly valuable for researchers in therapeutic methods, anti-aging treatments, and sports medicine, due to its synergistic effects.

Buy the TB500 and GHK-Cu peptide stack from Direct Peptides for research only. Enhance your tissue regeneration, wound healing, and anti-aging research with this advanced peptide combo.

Note: This product is intended for research use only and is not for human consumption. Ensure all research is conducted by licensed professionals to guarantee safety and authenticity. 

Buy TB500 and BPC-157 Blend

TB500 BPC157 Blend Peptide VialDiscover the synergistic power of the TB500 and BPC-157 peptide blend, a cutting-edge combination designed to accelerate the healing of muscles, tendons, and ligaments. This potent blend merges the angiogenic properties of TB500 with the robust tissue-repair abilities of BPC-157, making it an invaluable asset in sports medicine and injury recovery.

Ideal for researchers focusing on advanced medical treatments, sports recovery, and tissue regeneration, this peptide blend offers promising avenues for improving recovery times and enhancing overall tissue health. Buy TB500 and BPC-157 peptide blend exclusively from Direct Peptides for research purposes and unlock new possibilities in therapeutic and regenerative studies.

Note: This product is intended for scientific and educational research only and is not for human consumption. All research should be conducted by licensed professionals to ensure safety and authenticity.

Frequently Asked Questions (FAQs) about TB-500

What are the primary uses of TB500?

TB500 is primarily used in sports medicine and research to expedite muscle repair, enhance wound healing, and reduce inflammation. It has been studied for potential applications in treating heart diseases, neurological disorders, rheumatoid arthritis, chronic kidney disease, and sports-related injuries.

Is TB500 safe for human use?

While TB500 shows promising results in laboratory and experimental settings, its application for human consumption requires further scientific validation. TB500 can be used for vitro testing and research purposes, including vitro diagnostic purposes, to explore its effects on cell growth and tissue repair under laboratory conditions.

Is TB500 safe for all ages?

TB500 is primarily studied within controlled research settings and is not approved for use in individuals under certain years of age. Consult with a healthcare provider to determine its suitability based on specific conditions of use.

What is the future of TB500 research?

Research on TB500 continues to explore its full range of therapeutic benefits, particularly in regenerative medicine and chronic disease management. Its potential to improve healing processes and tissue repair makes it a significant focus of ongoing scientific studies.

Where can I find more scientific literature on TB500?

Resources from reputable institutions such as the George Washington University School of Medicine and Case Western Reserve University School of Medicine are valuable for detailed research and information on TB500.

Is TB-500 legal?

The legality of TB500 varies depending on the jurisdiction and the specific regulations governing the use of peptides and similar compounds. In the United States, the Food and Drug Administration (FDA) has not approved TB500 for human use, which means it cannot be legally marketed or sold for this purpose. However, it may still be available for research purposes under certain conditions.

In Australia, the Therapeutic Goods Administration (TGA) oversees the regulation of therapeutic goods including peptides. TB500 is not included in the Australian Register of Therapeutic Goods (ARTG), effectively rendering its sale and distribution for human use illegal without appropriate authorization.

Similarly, in the United Kingdom, the Medicines and Healthcare products Regulatory Agency (MHRA) regulates medical products. TB500 is not licensed for human use, and its sale and distribution are restricted to research purposes or under specific conditions stipulated by the MHRA.

Therefore, while TB500 can be acquired for scientific research and investigation, its use in humans remains subject to stringent regulatory frameworks and is generally prohibited in the aforementioned regions without proper clearance. Always consult legal and medical professionals to ensure strict compliance with local laws and regulations.

Summary of Research Applications

  • Accelerates extracellular matrix production and the healing of wounds 
  • Tissue repair
  • Neuroprotection
  • Cardiac repair
  • Autoimmune diseases
  • Control of infections
  • Muscle recovery and development

TB500 Peptide Quality Assured​

At Direct Peptides Czech Republic, we elevate the standard in peptide solutions by offering TB500 peptides with an unprecedented 99% purity guarantee. Our meticulous attention to detail during the synthesis process ensures that every batch surpasses the industry benchmarks for quality and efficacy.

This premium level of purity not only underscores our reputation for excellence but also maximises the therapeutic potential of TB500, providing our clients with a product they can trust to meet their research needs with unparalleled reliability.

Access the High-Performance Liquid Chromatography (HPLC) Certificate here.

References For Further Reading​

[1] P.Cheng et al. (2014) Beneficial effects of thymosin β4 on spinal cord injury in the rat – Neuropharmacology October 2014, volume 85, pages 408-16.

[2] M.Chopp and Z.G.Zhang (2015) Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases – Expert Opinion on Biology Therapy. 2015, volume 15 Issue Supplement 1:S9-12.

[3] H.Li et al (2019) Thymosin beta 4 attenuates oxidative stress-induced injury of spinal cord-derived neural stem/progenitor cells through the TLR4/MyD88 pathway – Gene, Volume 707, 30 July 2019, Pages 136-142

[4] K.N.Nube and N.Smart (2018) Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease – Expert Opinion on Biological Therapy Volume 18, 2018 – Issue sup1: Proceedings of the Fifth International Symposium on Thymosins in Health and Disease

[5] D.Philp et al (2007) Thymosin beta 4 induces hair growth via stem cell migration and differentiation – ANNALS of the New York Academy of Sciences, 2007 Sep:1112:95-103

[6] K.Maar et al (2021) Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies – Cells. 2021 Jun; 10(6): 1343

[7] K.M.Malinda et al. (1999) Thymosin β4 Accelerates Wound Healing – Journal of Investigative Dermatology 1999 Sep;113(3):364-8

[8] Y.Xiong et al. (2013) Neuroprotective and neurorestorative effects of Thymosin beta 4 treatment following experimental traumatic brain injury – Annals New York Academy of Sciences. Author manuscript; available in PMC 2013 Oct 1

[9] K.S.Kim and H.I.Yang (2017) Thymosin β4 in rheumatoid arthritis: Friend or foe (Review) – Biomedical Reports. 2017 Sep; 7(3): 205–208

[10] E.Vasilopoulou et al. (2015) The role of thymosin-β4 in kidney disease – Expert Opinion on Biological Therapy. 2015:15 Suppl 1:S187-90

[11] S.Shrivastava et al. (2010) Thymosin beta4 and cardiac repair – Annals of the New York Academy of Sciences. 2010 Apr:1194:87-96

Why Choose Direct Peptides Czech Republic?

Buy TB500 peptides today and discover unrivalled quality with Direct Peptides Czech Republic, your premier source for TB-500 peptides. Setting us apart is our unique array of TB500 formulations, including peptide vials available in 2mg, 5mg and 10mg, peptide blends and stacks with potential synergistic effects, peptide nasal sprays available in 15ml and 30ml spray bottles, pre-mixed peptide pens, and even peptide capsules. Catering to varied research needs, we ensure that researchers have access to the precise formulation required for their specific projects.


DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Czech Republic Direct Peptides website: https://czech-republic.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.